The Nobel Prize in Chemistry was awarded on Wednesday to Benjamin List and David W.C. MacMillan for their development of a new tool to build molecules, work that has spurred advances in pharmaceutical research and lessened the impact of chemistry on the environment. From a report: Their work, while unseen by consumers, is an essential part in many leading industries and is crucial for research. Chemists are among those tasked with constructing molecules that can form elastic and durable materials, store energy in batteries or inhibit the progression of diseases.
But that work requires catalysts, which are substances that control and accelerate chemical reactions without becoming part of the final product. “For example, catalysts in cars transform toxic substances in exhaust fumes to harmless molecules,” the Nobel committee said in a statement. “Our bodies also contain thousands of catalysts in the form of enzymes, which chisel out the molecules necessary for life.” The problem was that there were just two types of catalysts available: metals and enzymes.
In 2000, Dr. List and Dr. MacMillan — working independently of each other — developed a new type of catalysis that reduced waste and allowed for novel ways to construct molecules. It is called asymmetric organocatalysis and builds upon small organic molecules. “This concept for catalysis is as simple as it is ingenious, and the fact is that many people have wondered why we didn’t think of it earlier,” said Johan Aqvist, chairman of the Nobel Committee for Chemistry. Virtually everyone on the planet has come across a product that has benefited from a chemist’s expertise. The process of using catalysts to break down molecules or join them together is essential in industry and research.
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